LSP Research Projects
Individual LSP research projects engage faculty, students, and fellows with diverse skills from multiple institutions. Breakthrough research is a primary goal of the lab (followed by publication in leading scientific journals), but we also invest heavily in the development and maintenance of software and the invention of fundamentally new approaches to pre-clinical and clinical pharmacology. Multiple programs use our methods for discovering and developing new drugs to treat the most challenging indications (e.g., drug-resistant cancer, pain, and neurodegeneration).
LSP Center Programs
Many of our projects are supported with funding from multi-investigator “center” grants:
The Center for Cancer Systems Pharmacology (CCSP) studies the responsiveness and resistance of human tumors to anticancer drugs as well as the adverse effects that they cause. Part of the National Cancer Institute Center for Cancer Systems Biology Consortium.
The HMS LINCS Center collects and disseminates data and analytical tools needed to understand how human cells respond to perturbation by drugs, the environment, and mutation. Part of the NIH Library of Integrated Network-based Cellular Signatures (LINCS) Program.
The Harvard Tissue Atlas is developing methods to precisely profile the microenvironments of diverse human tumors. Supported by the NIH, Ludwig Cancer Research Foundation, the Bill and Melinda Gates Foundation, the Gray Foundation, and the Rossy Foundation.
The HMS PCA Center collects and analyzes highly multiplexed single cell data on early melanomas to better understand factors that promote their progression. Part of the NCI Human Tumor Atlas Network (HTAN).