We are reinventing the fundamental science underlying the development of new medicines and their use in individual patients.

The Laboratory of Systems Pharmacology (LSP) uses a team science approach to advance the fundamental science and technology needed to develop new medicines and personalized patient care.

We study the molecular causes of disease, how drugs exert their therapeutic and adverse effects, how clinical trials are designed and interpreted, and how machine learning and AI can help identify new molecular targets in diseases like cancer, Alzheimer’s, tuberculosis, and chronic pain. 

 

The LSP is a research and education program that is part of the Harvard Program in Therapeutic Science (HiTS). Our organization prepares students and fellows for leadership roles in academic research, industry, and government service.

News, Events, & Updates

Seminar Series

“Managing Data by Managing Metadata”

Stuart Levine, Ph.D. | Director of BioMicro Center, Massachusetts Institute of Technology

February 14, 1-2pm ET | Goldenson 122

Watch Previous Data to Discovery Seminars

LSP Articles Selected for Best of Cell 2023 and Nature Cancer’s 2023 in Review

An article from the Santagata and Sorger Labs, Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer,” 

was selected as the Best of Cell 2023. This project led to the development of one of the first 3D human tissue atlases, providing a

new perspective on the 3-dimensional structure and molecular properties of tumors.

 

Another article, “High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers,”

was highlighted in Nature Cancer’s 2023 in Review