Highlighted Publications

Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis.

Larkins-Ford J, Greenstein T, Van N, Degefu YN, Olson MC, Sokolov A, Aldridge BB.
Cell Syst. 2021 Aug 21:S2405-4712(21)00292-1. doi: 10.1016/j.cels.2021.08.004. Epub ahead of print. PMID: 34469743.

The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution.

Nirmal, A.J., Maliga, Z., Vallius, T., Quattrochi, B., Chen, A.C., Jacobson, C.A., Pelletier, R.J., Yapp, C., Arias-Camison, R., Chen, Y.-A., Lian, C.G., Murphy, G.F., Santagata, S., Sorger, P.K.
Cancer Discovery. 2022 Apr 11; candisc.1357.2021. doi.org: 10.1158/2159-8290.CD-21-1357. PMID: 35404441.

Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data.

Rashid R, Chen Y-A, Hoffer J, Muhlich JL, Lin J-R, Krueger R, Pfister H, Mitchell R, Santagata S, Sorger PK.
Nature Biomedical Engineering. 2022 May;6(5): 515–526. PMID: 34750536; PMCID: 9079188.

Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.

Mehta, AK, Cheney, EM, Hartl, CA, Pantelidou, C, Oliwa, M, Castrillon, JA, Lin, JR, Hurst, KE, … Mittendorf EA, Sorger, PK, Shapiro, GI, Guerriero, JL.
Nat Cancer. 2021 Jan;2(1):66-82. doi: 10.1038/s43018-020-00148-7. PMID: 33738458; PMCID: PMC7963404.

SYLARAS: A platform for the statistical analysis and visual display of systemic immunoprofiling data and its application to glioblastoma.

Baker GJ, Muhlich JL, Palaniappan SK, Moore JK, Davis SH, Santagata S, Sorger PK.
Cell Syst. 2020 Sep 23;11(3):272-285.e9. doi: 10.1016/j.cels.2020.08.001. Epub 2020 Sep 7. PMID: 32898474; PMCID: PMC7565356.

A switch in p53 dynamics marks cells that escape from DSB-induced cell cycle arrest.

Tsabar M, Mock CS, Venkatachalam V, Reyes J, Karhohs KW, Oliver TG, Regev A, Jambhekar A, Lahav G.
Cell Rep. 2020 Aug 4;32(5):107995. doi: 10.1016/j.celrep.2020.107995. Erratum in: Cell Rep. 2020 Nov 10;33(6):108392. PMID: 32755587; PMCID: PMC7521664.

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.

Daniels VW, Zoeller JJ, van Gastel N, McQueeney KE, Parvin S, Potter DS, Fell GG, Ferreira VG, Yilma B, Gupta R, Spetz J, Bhola PD, Endress JE, Harris IS, Carrilho E, Sarosiek KA, Scadden DT, Brugge JS, Letai A.
Sci Signal. 2021 Jun 8;14(686):eabc7405. doi: 10.1126/scisignal.abc7405. PMID: 34103421; PMCID: PMC8285073.

Prophages encode phage-defense systems with cognate self-immunity.

S.V. Owen, N. Wenner, C. Dulberger, E. Rodwell, A. Bowers-Barnard, N. Quinones-Olvera, D.J. Rigden, E.J. Rubin, E.C. Garner, M. Baym†, J.C.D. Hinton
Cell Host & Microbe (2021).

Machine learning identifies candidates for drug repurposing in Alzheimer’s disease.

Rodriguez S, Hug C, Todorov P, Moret N, Boswell SA, Evans K, Zhou G, Johnson NT, Hyman BT, Sorger PK, Albers MW, Sokolov A.
Nat Commun. 2021 Feb 15;12(1):1033. doi: 10.1038/s41467-021-21330-0. PMID: 33589615; PMCID: PMC7884393.