OpenFold provides insights into AlphaFold2’s learning behavior

AlphaFold2 has demonstrated impressive utility in predicting protein structure, but the lack of code transparency makes it challenging to understand the model’s learning process or re-train the code for specialized applications. This Research Highlight discusses OpenFold (published in Nature Biotech), a new open-source implementation of AlphaFold2 from LSP fellow Nazim Bouatta and Mohammed AlQuraishi. OpenFold performs with similar accuracy to AlphaFold2 and is more accessible and customizable for the broader protein folding community.