3D Imaging Maps the Hidden Landscape of Human Tumors

Harvard Medical School recently featured a new 3D imaging technique developed by LSP members Clarence Yapp, Alex Wong, and Daniel Lu. Their approach enables 3D imaging of thicker human tissue samples, capturing key cellular features that are often invisible or mischaracterized in traditional, thin tissue sections. As described in their recent Nature Methods paper, "Highly multiplexed 3D profiling of cell states and immune niches in human tumors", this method reveals protein markers and tissue architecture with unprecedented clarity, offering new insights into tumor biology and the immune microenvironment.

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