We are reinventing the fundamental science underlying the development of new medicines and their use in individual patients.
The Laboratory of Systems Pharmacology (LSP) uses a team science approach to advance the fundamental science and technology needed to develop new medicines and personalized patient care.
We study the molecular causes of disease, how drugs exert their therapeutic and adverse effects, how clinical trials are designed and interpreted, and how machine learning and AI can help identify new molecular targets in diseases like cancer, Alzheimer’s, tuberculosis, and chronic pain.
The LSP is a research and education program that is part of the Harvard Program in Therapeutic Science (HiTS). Our organization prepares students and fellows for leadership roles in academic research, industry, and government service.
Explore LSP Research
Twitter @Harvard_Lab
Out yesterday from Baker, Sorger, and colleagues, comes CyLinter--quality control software for high-plex tissue profiling. https://www.nature.com/articles/s41592-024-02328-0?utm_source=twitter&utm_medium=social&utm_campaign=nmeth
Caitlin Mills is the Director of Preclinical Pharmacology in the Laboratory of Systems Pharmacology at Harvard Medical School. We spoke to Caitlin at @ELRIG_UK Drug Discovery about a cell staining and fixation technique for drug screening >>> https://hubs.ly/Q02WsRjp0
This will be a terrific meeting, breaking new ground in matching the right cancer patient to the right drug, the promise of precision oncology.
🎉🚨Exciting News. Congratulations to our colleagues:
Gurkan Mollaoglu
Alexander Tepper
Chiara Falcomatà @ChiaraFalcomata
Alessia Baccarini @alessiabaccari4
Brian D. Brown @Brown_lab1
on identifying IL-4 signaling as a target to enhance ovarian cancer response to…
📰PAPER @CellCellPress from IGI Director Brian Brown shows how ovarian cancers evolve local neighborhood control and use IL-4 to resist anti-PD-1 immunotherapy. The findings support a key role for type 2 immunity in cancer and the possibility of drugging this pathway for therapy.