We are reinventing the fundamental science underlying the development of new medicines and their use in individual patients.
The Laboratory of Systems Pharmacology (LSP) uses a team science approach to advance the fundamental science and technology needed to develop new medicines and personalized patient care.
We study the molecular causes of disease, how drugs exert their therapeutic and adverse effects, how clinical trials are designed and interpreted, and how machine learning and AI can help identify new molecular targets in diseases like cancer, Alzheimer’s, tuberculosis, and chronic pain.
The LSP is a research and education program that is part of the Harvard Program in Therapeutic Science (HiTS). Our organization prepares students and fellows for leadership roles in academic research, industry, and government service.
Explore LSP Research
News, Events, & Updates
Seminar Series
March 13, 1-2pm ET | Goldenson 122
Watch Previous Data to Discovery Seminars
LSP Articles Selected for Best of Cell 2023 and Nature Cancer’s 2023 in Review
“Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer,” was selected as the Best of Cell 2023. This project led to the development of one of the first 3D human tissue atlases.
Another article, “High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers,”
was highlighted in Nature Cancer’s 2023 in Review.
Twitter @HiTSatHarvard
Truly excited to see our latest article, in which we were surprised how phages that target conjugative plasmids are both so common and diverse, published!
A real tour de force from @nquinoneso and @implosian
💯💯💯 deeply grateful to the American taxpayers for providing the primary funding for my lab's research on antibiotic resistance and biotechnology
MCMICRO, developed by @harvardmed #HTAN, is a microscopy pipeline for the processing and analysis of high-plex tissue images into #SingleCell data.
Now published @NatureCellBio📢 Using CRISPRi/a screening, we dive deep into the transporters driving essential nutrient import into cells. Discover more about amino acid transport, metabolism, ferroptosis, and environmental impacts on tumor growth here: https://rdcu.be/dErUO
Out today in @NatureCellBio: A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
Congrats @chidley_chris and team! 🎉